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Baseline and periodic blood pressure measurements, particularly in patients with cardiovascular disease or those taking cardiovascular medications, would identify any clinically significant hemodynamic effects
The Organization of Teratology Information Specialists (OTIS) maintains a registry of women treated with biologic or immunosuppressive medication during therapy
Preclinical data suggest potential neuroprotective mechanisms tied to mitochondrial support and anti-apoptotic signaling, hinting at experimental relevance in brain injury and age-related degeneration[1][11]
In cognitive peptides: substitute when possible in vivo tests by cerebral organoids or primary neuronal cultures ( Replacement ), optimise experimental plan to minimise the number of animals ( Reduction ), use appropriate anaesthesia and analgesia during invasive procedures ( Refinement )
