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However, exposure to AQ-QI or DEAQ-QI resulted in a rapid, marked activation of the ER stress response

Morris VK, Overman MJ, Eng C, Vilar Sanchez E, Morelli MP, Jiang Z, Luthra R, Maru DM, Meric-Bernstam F, Kopetz S

Mitochondrial dysfunction, indicated by reduced mitochondrial membrane potential (MMP), is also frequently observed in T1DM patients, resulting in compromised sperm motility [9, 11]

In vitro COMT inhibition assays demonstrated that the tolcapone-loaded PLGA nanoparticles achieved comparable enzyme inhibition efficacy to free tolcapone, confirming therapeutic retention which was achieved in addition to a controlled-release profile and reduced cytotoxicity