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Technical and biological hurdles are paramount, including the inefficient delivery of cells or vectors to widespread motor neurons across the central nervous system, host immune responses that can limit efficacy or durability, and unresolved long-term safety concerns such as off-target effects or uncontrolled cell differentiation (15, 60, 65)

Additionally, it has been observed to exhibit anti-migratory and anti-proliferative properties over time [185]

Sterile water (no preservative) : Often associated with shorter usable timelines

N Engl J Med 372:22682269 Olson RD, Mushlin PS, Brenner DE, Fleischer S, Cusack BJ, Chang BK, Boucek Jr RJ (1988) Doxorubicin cardiotoxicity may be caused by its metabolite, doxorubicinol