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Another group independently also concluded that disability progression and brain atrophy occur earlier than in the classical secondary progressive stage, with many relapsing patients exhibiting insidious progression without clinical or radiographic evidence of inflammatory disease activity, coining the term silent progression (Cree et al., 2019)

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In line with the RSL3 data, cholesterol rendered HT1080 cells more resistant to RSL3, cysteine starvation, erastin treatment as well as when GPX4 is deleted by CRISPR mediated knockout, with a comparable potency to Fer-1 (ferrostatin-1) (Fig