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A previous clinical trial aimed at correcting the HHcy induced by metformin in PCOS patients found that metformin did indeed significantly increase circulating Hcy and that folic acid reduced it only by 8% compared to a 21% reduction with a multivitaminic approach (B1, B6, and B12) [24]

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The Hospira bacteriostatic water for injection contains 0.9% benzyl alcohol, making it suitable for multi-dose use

Its key advantages are prolonged sterility (multi-dose use) and slight anesthetic effect, but it must be used correctly: always dilute drugs per guidelines, ensure the final solution is isotonic, and heed contraindications (no neonates, no intrathecal use)