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The existing antidepressant drugs mainly target the dysfunctions of various neurotransmitters, while the efficacy of antidepressant therapeutics is undermined by different adverse side-effects

Intravenous glutathione administration offers the highest bioavailability but requires medical supervision and is typically reserved for specific therapeutic purposes

Comparison of [ 3 H]resiniferatoxin binding by the vanilloid (capsaicin) receptor in dorsal root ganglia, spinal cord, dorsal vagal complex, sciatic and vagal nerve and urinary bladder of the rat

The proposed mechanism is indirect modulation of the NO pathway rather than direct receptor agonism, though the precise molecular binding event has not been definitively characterized in peer-reviewed work