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Poprac P, Jomova K, Simunkova M, Kollar V, Rhodes CJ, Valko M (2017) Targeting free radicals in oxidative stress-related human diseases

The mechanisms of the progressive degeneration of RGCs and their axons in glaucoma have been attributed to various factors, such as the elevation of IOP, the activation of immune cells, altered trabecular meshwork (TM) cells, and dysregulated gut microbiota

This acylation facilitates reversible binding to serum albumin, creating a circulating depot that significantly extends its pharmacokinetic profile, making it an ideal tool for long-term metabolic studies in preclinical models