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Similarely, a 6-month exposure of Sprague-Dawley rats to cigarette smoke significant increased ANG II levels and ACE protein expression and decreased ACE2 expression in lung tissue (Yuan et al., 2015)

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The Lung Foundation Australia ((b) n.d.) emphasises that nicotine e-cigarettes have not been approved by the Therapeutic Goods Administration (TGA) or any equivalent foreign medicine regulator as a proven smoking cessation tool. In simpler terms, vapes are yet to be approved by TGA for their safety, quality, and effectiveness in helping people quit smoking

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