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Liver dysfunction, caused by factors such as alcohol abuse, toxins, or diseases, can significantly impair glutathione synthesis
Effective in treating pigmentation post-freckles, ephelides, or infection
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This second process means that the GSH:GSSG ratio measured in tissue or whole cell extracts does not report on the actual glutathione status in specific compartments but is rather a composite value of GSH:GSSG ratios, which may differ widely between different subcellular locations (Noctor et al., 2013)
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