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6 Novel therapeutic avenues and future directions 6.1 Immunotherapy and targeted molecular treatments Recent studies have identified the calcitonin gene-related peptide (CGRP)/receptor activity modifying protein 1 (RAMP1) signaling axis as a critical player in endometriosis pathophysiology, with implications for both lesion development and pain generation ( 6.2 Ferroptosis modulation and oxidative stress control Iron overload resulting from periodic bleeding is a characteristic feature of endometriosis, which contributes to oxidative stress and plays a crucial role in the pathogenesis of endometriosis and its associated infertility

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Therefore, since Leishmania is an intracellular parasite, we concur with several authors who emphasize the importance of localizing iron overload within macrophages, where the battle between the immune system and the parasite takes place