Glutathione (GSH) is a major antioxidant and its depletion increases oxidative stress and extensive carbonylation of proteins (10, 11, 1618)
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In the presence of specific ferroptosis-inducing agents, baicalein exhibited superior anti-ferroptosis activity compared to established ferroptosis inhibitors such as ferrostatin-1, liproxstatin-1, desferrioxamine mesylate, and -mercaptoethanol (71, 74)
COX transfers electrons to oxygen and eventually water is formed, and, at the same time, protons are pumped through the inner membrane of the mitochondria