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-KG formation can be catalyzed by either glutamate dehydrogenase (GDH) or aminotransferases

172 In one study that included 92 women and 46 men undergoing assisted reproductive treatment and 161 controls, MTHFR mutations were correlated with poor in vitro fertilization outcomes and embryonic chromosomal abnormalities

Research suggests these dual angiogenic signaling routes might indicate that BPC157 engages overlapping vascular regulatory mechanisms, potentially enabling angiogenic responses across tissue environments with differing baseline growth factor availability

For in vivo studies, the number of animals used must be kept to an absolute minimum [472]