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Many patients who do not meet hypermobile EDS criteria and do not have clear evidence for another specific syndrome will meet criteria for hypermobility spectrum disorders

References Sozen, T

This increase in AcCa species aligns with the hypothesis of altered mitochondrial fatty acid utilization in mutant CMs, consistent with previously observed changes in mitochondrial respiration

Regarding efficacy, in the 137 analyzed patients, the change from baseline to the end of observation in Visual Analogue Scale score (VAS) was statistically significant, ranging from 75.9 1.56 to 51.9 1.99 ( p 40 according to the VAS score (Visual Analogue Scale 0100), who, between 2017 and 2022, were prescribed ALC, regardless of the concomitant pharmacological FMS therapy (add-on treatment)