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In hypertensive rodent models, ginsenoside Rg1 and Rb1 enhanced endothelium-dependent relaxation and reduced blood pressure, linked to activation of the Akt/eNOS pathway and inhibition of NADPH oxidase-derived ROS

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The overarching material developed and investigated comprises AngIV-based compounds, designed to overcome the limitations of native peptides like AngIV, which suffer from poor metabolic stability and inability to cross the BBB due to their size and hydrophilicity

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