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6 The evolutionary diversity of extant SODs is thought to arise in part from a series of gene duplication events, later selected during the earths geological changes, e.g., the great oxygenation event, or as an adaptation of pathogens to host-imposed stresses, including nutritional immunity and ROS exposure

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It has been found to have a wide range of therapeutic effects, including promoting tissue regeneration, reducing inflammation, and protecting against oxidative stress