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Description

The mechanistic framework for the gastrointestinal effects overlaps with the tissue-repair framework: NO-system modulation, mucosal microcirculation, and angiogenic-pathway support all appear in both literatures

In all selected studies, male adult rats were used, Wistar [26, 29, 31] and Sprague Dawley [27, 28], except for one study that used adolescent albino rats [30]

Epub 2007/05/25

Complementary to the above, it has been thought for a long time that only supraphysiological concentrations of IGF-1 are able to activate the IR, as will be further discussed in this manuscript