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doi: 10.1073/pnas.1511706112 Cardoso, Fernanda C., Deka, Zoltan, Rosengren, K

Still, some early clinical findings hint at potential uses in more specific contexts: Perioperative brain protection: A randomized controlled trial involving 155 liver surgery patients found that ALA reduced oxidative brain injury from anesthesia (sevoflurane) and improved cognitive recovery scores after surgery.31 Neurodegenerative conditions: In a small trial, ALA appeared to slow brain atrophy in patients with secondary progressive multiple sclerosis over a two-year period.32 While promising, this outcome still needs further confirmation

This protective effect extended to other stressors, as glutathione amino acid precursors also shielded cells from blue light-induced ROS production and pollutant-induced ATP depletion, demonstrating a broad-spectrum protective action