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Experiments can be conducted in a variety of environments (vacuum, steam, fumes), with two operation modes (contact and intermittent contact) available

Federico L, Haymaker C, Forget MA, Ravelli A, Bhatta A, Karpinets T, Zang R, Fang B, Zhang J, Wagner H, Bogatenkova E, Wistuba I, Sepesi B Heymach J, Gibbons D, Bernatchez C, Weissferdt A, Vaporciyan A, Futreal A, Zhang J, Lizee G, Talukder A, Roszik J, Tran H, Wagner H, Behrens C, Parra E, Caneles JR, Fujimoto J, Allison J Sharma P, Vence L, Roth J, Meraz I, Roarty E, Lacerda L, Byers L, &S, William Jr W

What this basically means is that the ordinary neurochemicals needed within the sympathetic nervous system can go on to stimulate hyper-excitable sensory cells in the DRG, and this produces the sensation of pain