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In general, there was a pattern of increasing numbers of tumor-bearing animals and total tumors with increasing doses of tar among groups of mice treated with low, medium, or high concentrations of expanded shredded tobacco stems

However, there is limited scientific evidence to support these claims

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The analysis acknowledges that "revenue losses would occur due to lower consumption of tobacco products due to the higher excise taxes" although the decline in smoking "appears to have stalled in recent years." So legislative analysts acknowledge that a dramatic tax hike from 87 cents per pack to $2.87 is high enough to depress revenue over time