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- **pCREB:** Regulates circadian rhythm and may reduce tumor growth

TLRs recognize antigens through pathogen-associated molecular patterns (PAMPs) or damage-associated molecular patterns (DAMPs)

SAM serves as a major methyl group donor in numerous methylation reactions across various tissues, particularly within the central nervous system, working in reactions that form phospholipids and biogenic amines (65, 67)

Interestingly, at least 20 cases show that COVID-19 patients experienced clinical parkinsonism following SARS-CoV-2 infection [17], pointing to a potential link between COVID-19 infection and newly formed parkinsonism