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196 Although the mutation frequency of E3 ubiquitin ligase is lower than that of other WNT inhibitors, mutations of RNF43 (which mediates ubiquitin degradation of Frizzled) are still detected in the adenoma tissues of patients with GC, 218 early-onset metastatic CRC, 219 and Lynch syndrome

The safety profile is comparable to other established GLP-1 therapies, with the added benefit of once-weekly dosing improving patient compliance

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Therapy continues as long as positive changes occur and is adjusted or discontinued if plateaus develop or goals are achieved