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Studies using high-field MRI and postmortem human brain tissues further confirm that excess iron destabilizes the labile iron pool, enhances ROS production via Fenton chemistry, disrupts respiratory chain function, alters bioenergetics, and promotes protein, DNA, and lipid damage through oxidative stress (250, 251)

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However, the risk profile includes potential issues like insulin sensitivity changes or, in rare cases, prolactin elevation, which is why monitoring is key

In this work, the authors were able to counter the increased proton leak and mPTP opening by ubiquinone analogs [336]