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Functionally, loss of Bmal1 in astrocytes promotes neuronal death in vitro

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This balance can become skewed and contribute to maladaptive plasticity, leading to aberrant learning underlying withdrawal syndromes and certain symptoms of non-addiction psychiatric disorders (Tayfun Uzbay and Oglesby, 2001

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The Mthfr / mice were with none MTHFR enzyme activity in all tissues, whereas the Mthfr +/ showed 60% residual activity, similar to the value observed in patients homozygous for the C667T polymorphism 40

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