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[84] [85] The 5-reductase inhibitors are contraindicated in pregnant women because of their teratogenicity due to interference with fetal testosterone metabolism, and as a precaution, pregnant women should not handle crushed or broken tablets

The mitochondria (M) were moderate in number, small in volume, without obvious swelling, with an intact membrane and a deep matrix density

Further study showed that L-theanine could obviously increase the expression of Bcl-2 mRNA and protein, decrease the expression of Bax, a pro-apoptotic molecule, and decrease the phosphorylation of ERK1/2 and c-Jun NH2-terminal kinase (JNK1/2) MAPKs (87)

DRP-104 is a prodrug of DON that is currently undergoing clinical trials (NCT04471415)