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Replacement of proteins by the artificial small-sized dimeric macrocycles seems to have advantages for drug development, such as production by chemical synthesis and amenability to chemical modifications for the control of pharmacokinetics, protease resistance and drug delivery, and such controlled properties should be carefully evaluated in future research and development

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However, none of the treatments could fully restore the disc height or achieve the same MRI T2 signal intensity as the healthy disc [96]

Triple Action Mechanism: Under investigation for its roles in collagen and elastin production, anti-inflammatory signaling, and antioxidant enzyme activation offering a unique tool for studying multi-target tissue restoration