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The primary role of GSTs is to detoxify xenobiotics by catalyzing the nucleophilic attack by GSH on electrophilic carbon, sulfur, or nitrogen atoms of said nonpolar xenobiotic substrates, thereby preventing their interaction with crucial cellular proteins and nucleic acids

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While studies have identified key regulators of GPX4-restricted LPO and cellular demise 1,2,6,12,13,14 , mechanism(s) of concurrent inflammatory responses remain elusive

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