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We did not stipulate cessation before scanning to avoid possible withdrawal effects and participants may have used nicotine on the day of scanning

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While Fe 3 can also generate radicals from peroxides, the reaction rate is approximately ten times slower than that of Fe 2 (Kehrer 2000) The term Fenton reagent refers to a mixture of HO and ferrous salts, an effective oxidant for a wide variety of organic substrates

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