Abbreviations AD: Alzheimers disease A: Amyloid-beta MOA: Mechanisms of action KEGG: Kyoto Encyclopedia of Genes and Genomes ADME: Absorption, distribution, metabolism, and excretion TCMSP: Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform DMSO: Dimethyl sulfoxide PMSF: Phenylmethylsulfonyl fluoride RIPA: Radioimmunoprecipitation assay ELISA: Enzyme-linked immunosorbent assay i.p: Intraperitoneal WT: Wild-type OF: Open field NOR: Novel object recognition MWM: Morris water maze PBS: Phosphate-buffered saline IHC: Immunohistochemistry qRT-PCR: Quantitative reverse transcription polymerase chain reaction FPKM: Fragments per kilobase of transcript per million mapped reads DEGs: Differentially expressed genes Gapdh: Glyceraldehyde-3-phosphate dehydrogenase SEM: Standard error of the mean ANOVA: Analysis of variance H&E: Hematoxylin and eosin 5-HT: 5-hydroxytryptamine GLP-1R: Glucagon-like peptide-1 receptor NTR1: Neurotensin receptor 1 APP: Amyloid precursor protein NOS1: Nitric oxide synthase TrkA: Neurotrophic tyrosine kinase receptor 1 NO: Nitric oxide NGF: Nerve growth factor References Scheltens P, De Strooper B, Kivipelto M, Holstege H, Chtelat G, Teunissen CE, et al
B12 supports this process by promoting red blood cell production, which ensures oxygen delivery to tissues and facilitates nutrient absorption
GHRHs (like Tesamorelin and Mod GRF 1-29) work by stimulating the production and release of natural growth hormone lines, while GHRPs (like Ipamorelin) amplify that signal and suppress somatostatinthe hormone responsible for halting growth hormone release
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