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doi:10.1016/bs.vh.2022.01.011 Kumrungsee T, Peipei Z, Yanaka N, Suda T, Kato N

This continuous cycle of DNA damage, inadequate repair, and apoptosis significantly exacerbates neuronal loss, making oxidative DNA damage a critical driving force in the pathogenesis of neurodegenerative diseases [136,137,138]

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Peter Attia, a longevity physician, discusses NAD+ precursors: "While evidence is emerging, NAD+ boosting shows promise for mitochondrial health and longevity, though IV might not be optimalprecursors like NMN could be better."[33][20] On combinations, he cautions on long-term data but notes potential for metabolic disorders