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Acta Physiologica Sinica 2006

The disruption of immune tolerance leads to aberrant expression of major histocompatibility complex molecules, co-stimulatory molecules, and anti-inflammatory cytokines in the liver, thereby mediating hepatic injury ( + and CD8 + T cells while diminishing the suppressive function of Tregs, as evidenced by biopsy findings from patients experiencing immune-related hepatotoxicity ( + /CD8 + T cells play a crucial role in the digestive system-related AEs mentioned above

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Instead of focusing on a single number, focus on a plan: why you're using it, what you'll monitor, and when you'll reassess