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The slow titration (125 mcg weeks 1-4, then 250 mcg weeks 5-8) mimics FDA-approved protocols that emphasize gradual increases for tolerability

IL-6 and its role in IgA nephropathy development

[52] in a retrospective review state that 5ARI usage of 4 years or more is associated with an increased incidence of high grade prostate cancers with worse progression

Rather than putting the patients through multiple repertoires of surgical procedures, none of which definitively culminates in a complete recovery or mitigation of intractable pain, TPIAT could be performed in advance once a differential diagnosis is made and eligibility is evaluated