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Moreover, intersections between upregulated DEGs in the control group and downregulated DEGs in the treatment groups, as well as between downregulated DEGs in the control group and upregulated DEGs in the treatment groups, also demonstrated that the combination group had a greater overlap with the control group than either single-drug group did (Additional file 2: Figure S5)

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Janku F, Zhang S, Waters J, Liu L, Huang H, Subbiah V, Hong DS, Karp D, Fu S, Cai X, Ramzanali NM, Madwani K, Cabrilo G, Andrews DD, Zhao Y, Javle M, Kopetz S , Luthra R, Kim HJ, Gnerre S, Satya RV, Chuang HY, Kruglyak KM, Toung J, Zhao C, Shen R, Heymach J, Meric-Bernstam F, Mills GB, Fan JB, Salathia NS