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Mouse experiments were performed in accordance with institutional guidelines of the Medical University of Innsbruck and following approval by federal authorities (BMWFW-66.011/0061-WF/V/3b/2016, BMBWF-66.011/0085-V/3b/2018 and BMBWF-66.011/0160-V/3b/2019 (Innsbruck)

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